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Therefore, women of childbearing age should not plan to conceive while on tirzepatide
By: Cami Eastman, RDN, LD on 02/26/2026 As more people in midlife turn to GLP-1 medications for metabolic support, questions are emerging about how these drugs interact with hormone replacement therapy (HRT), what the long-term effects may be for postmenopausal bodies, and what nutritional strategies are most important to protect health
Its important to rotate sites to reduce the risk of skin irritation
In terms of tolerability, tirzepatide generally causes fewer gastrointestinal side effects, making it a better option for those sensitive to nausea, while Semaglutide GLP-1 may cause mild to moderate gastrointestinal issues like nausea and diarrhea, which usually subside over time
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