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Older adults, people on stimulants or sympathomimetics, and those who become dehydrated from reduced intake or severe gastrointestinal side effects are more likely to show exaggerated heart rate responses
Safety analyses included all dosed participants, and pharmacokinetics/pharmacodynamics analyses included all participants with quantifiable pharmacokinetics/pharmacodynamics data
If there is no improvement in 24 hours, then you should raise again to another 10%
Vomiting was reported in 25/140 (18%) VK2735-treated patients compared with none reported among patients receiving placebo
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