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3 To help guide dosing decisions, use the estimated glomerular filtration rate (eGFR) instead of the serum creatinine (SCr) level, because the SCr can translate into a variable range of eGFRs ( TABLE 1 )

Gastrointestinal bleeding refers to any bleeding that starts in the gastrointestinal tract, which is the part of the body involving the stomach and intestines

It appears that extensive oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids might modify membrane structure and increase membrane permeability, eventually resulting in plasma membrane rupture in response to accumulation of lipid-ROS, e.g., lipid hydroperoxides

Adequate hydration and fiber intake help manage the constipation that sometimes occurs with these medications