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How Does Retatrutide Affect Metabolic Biomarkers
The STEP UP trial data provides the foundation for this approval
For instance, in a clinical randomized trial of 52 patients with T2D, 16S rRNA profiling showed that 6 weeks of liraglutide (or colesevelam) did not produce discernible changes in gut microbiota composition, even though patients experienced altered bile acid profiles ( However, another study in diabetic patients showed functional genetic predictions indicating that liraglutide might increase microbial genes associated with improved carbohydrate and lipid metabolism, suggesting a shift toward a healthier functional capacity of the gut microbiota ( Other human studies have reported microbiota changes concordant with those seen in animal models
More frequent monitoring may be appropriate, and coordination with your mental health team ensures comprehensive care
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