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This energy crisis is further compounded by specific metabolic deficiencies

Indian J Exp Biol 45:10451049 Anto SK, Koyada N, Khan S, Jena G (2016) -Lipoic acid attenuates transplacental nicotine-induced germ cell and oxidative DNA damage in adult mice

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When hepatic lipid export is impaired, triglycerides accumulate in liver cells (hepatic steatosis), which disrupts insulin signaling and shifts metabolism toward fat storage rather than fat oxidation