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This makes detection and quantification particularly challenging: sensitive and highly selective methods are often required to distinguish these impurities from the main peptide
Semaglutide works reliably , but the ceiling appears to be around 15% for most patients
For weight management specifically, the FDA has approved semaglutide 2.4 mg weekly (Wegovy), liraglutide 3.0 mg daily (Saxenda), and tirzepatide (Zepbound) for adults with BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity
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