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The phase 2 trial published in The New England Journal of Medicine in 2023 enrolled adults with obesity without type 2 diabetes and demonstrated dose-dependent weight loss of up to 24.2% of body weight at the highest dose over 48 weeks results that attracted considerable scientific and media attention
For oral semaglutide (Wegovy pill, Rybelsus), it should typically be taken once daily on an empty stomach, ideally at the same time each day
Conversely, point estimates for tirzepatide showed a potential modest advantage for heart failure endpoints, with CIs compatible with no difference, consistent with recent data supporting protective effects of semaglutide and tirzepatide on heart failure outcomes and a potential incremental benefit with the latter 22
00:27:46 Jennifer Clements Again, I think theres many different factors that go into it
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