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How Wegovy Affects Your Lipid Panel: Cholesterol, Triglycerides, and LDL Changes on Semaglutide 2.4 mg At a glance Drug / Wegovy (semaglutide 2.4 mg), a once-weekly GLP-1 receptor agonist Triglycerides / Reduced by approximately 12% to 18% across STEP trials LDL cholesterol / Decreased by roughly 3% to 4% from baseline Total cholesterol / Lowered by approximately 2% to 4% versus placebo HDL cholesterol / Increased modestly by 1% to 3% in most trial arms VLDL cholesterol / Decreased in proportion to triglyceride reductions Timeline / Lipid improvements measurable by week 16, sustained through week 68 Mechanism / Both direct GLP-1 receptor effects on hepatic lipid metabolism and indirect weight-loss-mediated improvements Monitoring / Baseline lipid panel recommended before starting, repeat at 3 to 6 months SELECT trial / Semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in patients with established cardiovascular disease What Happens to Your Lipid Panel on Wegovy Wegovy shifts nearly every marker on a standard lipid panel in a favorable direction

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