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Some, but not all, observational studies have suggested that GST genotypes could influence the associations between cruciferous vegetable consumption and risk of disease (59)

Mechanistically, silencing P2X4 blocks the NLRP3/caspase- 1 pathway, demonstrating a neuroprotective effect in an intracerebral hemorrhage mouse model, while administration of an NLRP3 activator induces neuronal impairment in the same model (Wu et al

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This study program named SURPASS comprises six global, two Japanese, and one Asian-Pacific study (69)