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Furthermore, the oncogenic transcription factor c-JUN was found to regulate the gene expression of GLS [108]

Key Takeaways Semaglutide's 7-day half-life (longest among GLP-1 agonists) creates natural stability, making split dosing effects more subtle Microdosing could reduce peak-to-trough ratios by 20-35%, potentially minimizing GI side effects Mathematical models suggest maintained efficacy (~80-95%) with twice or thrice weekly dosing Semaglutide is FDA-approved for weekly dosing only

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