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As glycaemia already underwent alterations following OB injections (prior to the administration of glucose), the AUC was measured from baseline (before OB injections, t-12 min) until t30 following insulin delivery (t0)
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The REDEFINE 2 trial examined the combination in adults with type 2 diabetes, where weight loss is typically harder to achieve due to insulin resistance and medication effects
Others are temporarily converted into reactive intermediates that must be rapidly neutralized by glutathione or another conjugation pathway
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