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Ashapkin, Linkova, Khavinson, and Vanyushin reported in 2015 that peptides such as KEDW and AEDL tissue-specifically affected gene expression in pancreatic and bronchial cell cultures, respectively, and that DNA-methylation patterns in certain gene promoter regions (including PDX1, PAX6, NKX2-1, and SCGB1A1) shifted with aging in correlation with expression changes
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While intracellular Ca 2+ regulation and ion channel activity are proposed to be important in endometrial function, their precise roles remain largely unexplored, at least partly due to the lack of relevant in vitro models
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