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Indications: Overactive bladder Common symptoms include urgency, urinary incontinence, and increased urinary frequency Side Effects: urinary retention pruritus, rash constipation Pharmacokinetics: taken orally by tablet, 75 mg once daily hepatic metabolism predominantly by CYP3A4 vibegron does not inhibit CYP2D6 (unlike mirabegron), so its pattern of drug interactions differs from mirabegron vibegron is a P-gp substrate half life ~31 hours Drug Interactions: increases digoxin Cmax (21%) and AUC (11%) Notes: Vibegron is a newly approved drug, and the estimated Walmart cost for Gemtesa oral 75mg tablets is ~$485 for a supply of 30 tablets (GoodRx.com
Qian W, Liu D, Liu J, Liu M, Ji Q, Zhang B, et al
(2003) Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia
IM injections use standard sites (deltoid, gluteal, vastus lateralis) and standard technique as described in peptide injection guides
