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It can also cross your blood-brain barrier, which can cause side effects like appetite loss, sexual dysfunction, and fatigue
The sexual function effects of MT-2 are centrally mediated through hypothalamic melanocortin circuits, not through peripheral vascular mechanisms, which distinguishes MT-2 from PDE5 inhibitors and explains its effectiveness in patients where desire and arousal motivation, rather than vascular mechanics, is the limiting factor
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It depends on factors such as weight, diet, and PCOS severity
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