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However, if heart rate effects are accompanied by palpitations, chest discomfort, or significant exercise intolerance, dose reduction is appropriate
HECT and RBR ligases form covalent thioester intermediates with ubiquitin prior to substrate transfer, whereas RING-type ligases, the most abundant class, mediate the direct transfer of ubiquitin from E2 to the substrate
Helps reduce pain and soreness following exercise
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