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The Limitations You Should Know: Dependency, Cost, and Side Effects Despite benefits, GLP-1 medications present challenges such as dependency, rebound weight gain upon stopping treatments, high costs especially in emerging markets, and side effects like nausea or digestive discomfort
Additionally, increasing the intake of foods rich in antioxidants (vitamin C, E, selenium) and phytoestrogens (soy isoflavones, flaxseed lignans) can assist in alleviating menopausal symptoms and oxidative stress damage
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Of note, in the STEP 1 extension trial, participants regained roughly two-thirds of their lost weight within a year of stopping semaglutide, and improvements in blood pressure, cholesterol, and glucose largely reversed
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