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Mechanistically, these single-nucleotide polymorphisms (SNPs) within intronic regions of EPAS1 reduce mRNA expression by diminishing promoter activity, thereby contributing to lower hemoglobin concentrations in Tibetan populations [6, 7]

Therefore, cagrilintide has broader amylin/calcitonin receptor receptor activity than selectively designed eloralintide and is often described as nonselective in comparative research

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