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The adduct was purified by size-exclusion chromatography and concentrated to ~10 mg ml 1

In early 2026, Roche paid $100 million to secure a non-exclusive patent licence from Structures subsidiary Gasherbrum Bio, covering intellectual property relevant to CT-996, the oral GLP-1 compound Roche acquired through its $2.7 billion buyout of Carmot Therapeutics in late 2023

These occur because food moves more slowly through the digestive tract

These actions are hypothesized to involve the activation of the PKA pathway and inhibition of the NF-B pathway, which are considered crucial in reducing neuroinflammation and promoting neuronal survival