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The clinical evidence for B12 depletion on GLP-1 therapy The data is consistent, if not yet overwhelming
Key advantages highlighted in recent clinical data include: Significant weight reduction in head-to-head comparisons with oral semaglutide No strict food or water timing restrictions Easier transition from injectable GLP-1 therapies to oral treatment Small-molecule stability with no refrigeration requirements If approved, this could improve accessibility, adherence, storage, and global distribution compared with many current peptide-based GLP-1 therapies
Other studies found no strong link in clinical trials, but some users on social media are saying they experienced breakouts when first starting on GLP-1 medication
Staying informed and working closely with your healthcare provider will be important
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