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Promising results have been observed for the GLP-1/GIP agonist LY3298176 in overweight or obese people with T2D, noting a weight loss between 0.9 and 11.3 kg in participants using the dual agent compared with 0.4 kg and 2.7 kg in those using placebo or dulaglutide respectively [52]
Symptoms include sweating, shakiness, and weakness, typically occurring within 1 week to 4 months of starting supplementation at no specific dose [36]
Common side effects include nausea, vomiting, and diarrhea, which can be managed by adjusting the dose or taking the medication with food
Immunohistochemical staining for GLP1-R, insulin, and proinsulin immunoreactivity Membranous immunoreactivity of GLP- 1R and cytoplasmic immunoreactivity of insulin and proinsulin were evaluated semi-quantitatively using the immunoreactive score (IRS) [17]
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