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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly
Genistein Genistein is an isoflavone, the best-known source of which is soybeans, and widely available as a nutritional supplement (Liggins 2000
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In short, any dosing figure circulating for dogs is an extrapolation, not a validated veterinary protocol
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