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Lynch SV, Pedersen O
The STEP-HFpEF trial was designed to evaluate the effects of treatment on symptoms and physical limitations, exercise function and inflammation, along with body weight, and was, therefore, not powered to assess clinical endpoints such as HF hospitalizations
While not necessarily dangerous, injecting into the muscle can change the rate at which the medication is absorbed, potentially leading to more side effects or reduced effectiveness
Patients with this condition or those with a family history suggestive of Lebers disease should avoid cyanocobalamin-containing products or use alternative forms of vitamin B12 such as hydroxocobalamin under careful medical supervision
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