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The receptors essentially become fatigued, triggering a process called beta-arrestin mediated internalization where the receptors are pulled from the cell surface and recycled internally
The elevated cAMP and Ca 2+ were observed following GPBA-R activation in single GLUTag cell, and bile acid and GPBA-RA increased GLP-1 secretion in intestinal cultures (Parker et al., 2012b)
Compound specificity: the exact molecular structure of interest
While only certain GLP-1 medications are FDA-approved to treat obesity, others are being used off-label for their weight loss benefits
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