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Wnt ligands bind to Frizzled receptors on the cell surface, resulting in the increased stability of cytoplasmic -catenin, and its subsequent translocation into the nucleus, where it activates the transcription of MITF by interplay with lymphoid enhancer-binding factor 1 (LEF1)/T-cell factor (LEF1/TCF) (26)

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A 2024 study published in the Journal of the American Medical Association Ophthalmology observed the incidence of NAION among people who were taking semaglutide for either weight loss or type 2 diabetes management