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Regulatory feedback mechanisms leading to an increase in the dietary absorption of LC, and/or de novo synthesis may take place to overcome the LC deficiency and reduce the loss by urinary excretion

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Pooled results from seven non-pharmacological trials were associated with a statistically significant 48% relative reduction of TIN risk with low heterogeneity and the pooled results from six pharmacological trials were associated with a significant 20% relative reduction of TIN risk with moderate heterogeneity

Methods Psychiatr