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References Veech, R
The general mechanism of liposomal drug delivery follows the implantation of drug molecules within the aqueous core of the liposome, using the lipid bilayer, ensuring its protection from the bodys aqueous environment
By inhibiting P-gp, these agents enhance cellular drug retention but may inadvertently increase systemic drug concentrations, posing toxicity risks for narrow-therapeutic-index medications (e.g., chemotherapeutics, cardiovascular drugs) (32, 8890)
"The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediates"
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