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Of interest, although liver-derived IGF-I has endocrine effects on extrahepatic tissues, there are only few data regarding local effects of this hormone in the liver[87] probably due to the very low amount of IGF-I receptors on the hepatocytes membrane[46, 88, 89]

The weekly dosing convenience is one reason GLP-1 medications have gained such widespread adoption, with many patients preferring one injection per week to the daily injections that insulin protocols require