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The lon-2(e678) mutant is known to upregulate TGF- signalling, leading to increased collagen synthesis 36,37
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At the same time, oxidative stress, which is caused by mitochondrial damage, activation of NADPH oxidase, and other environmental or treatment-related insults, promotes tumourigenesis through a cascade of events including: oxidative DNA adducts (8-oxo-dG), lipid peroxidation (4-HNE), protein oxidation, redox-regulated oncogene activation and mutagenesis, inhibition of the DNA repair machinery, and a vicious cycle of genomic instability accompanied by inflammatory signalling (178180)
Discussion 1) The research team of Lau et al evaluated the efficacy and safety of the amylin analogue Cagrilintide for weight management
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