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Regardless of what contributes to the disorder, treatment has one central goal: reduce pressure and irritation around the median nerve before prolonged compression causes lasting sensory loss, weakness, or muscle degeneration

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Chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis leads to prolonged elevation of cortisol, which can downregulate serotonin and dopamine receptor expression in areas such as the prefrontal cortex and limbic system, contributing to mood disorders and impaired cognitive function

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