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In addition, all subjects attended four-weekly telephone follow-up visits with a healthcare assistant which aimed to reduce discontinuation and offer additional time to stabilise before subsequent dose escalation

Patient Management and Practical Recommendations Pre-Treatment Tests B12 and Biomarker Panel: Baseline blood tests checking Vitamin B12, Folate, Methylmalonic Acid (MMA), and Homocysteine levels to confirm the exact type and severity of the deficiency

Tryptophan, for instance, helps the brain produce serotonin, which supports emotional stability and restful sleep