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Notably, the addition of RSV to PEG + PC liposomes significantly mitigated hemolytic toxicity, maintaining hemolysis below 3% across all concentrations, comparable to PEG-only formulations (Supplementary data)
2024 DOI: 10.1038/s41421-024-00702-y PMID: 39019866 Read on PubMed European Journal of Clinical Pharmacology A review of an investigational drug retatrutide, a novel triple agonist agent for the treatment of obesity Kaur M, Misra S 2024 DOI: 10.1007/s00228-024-03646-0 PMID: 38367045 Read on PubMed Cardiology in Review The First Triple Agonist for Antiobesity: Retatrutide Tetelbaum L, Mullally JA, Frishman WH 2024 DOI: 10.1097/CRD.0000000000000793 PMID: 39724554 Read on PubMed NPJ Metabolic Health and Disease Incretin triple agonist retatrutide alleviates obesity-associated cancer progression Marathe SJ, Grey EW, Bohm MS, et al
Patient-level weight change data were unavailable, so the analysis cannot explain whether the observed differences were driven by weight loss, metabolic control, cardiovascular effects, direct tumor biology, or differences in patient selection
The GLP-1 release (pM) in each incubated fragment was normalized to the quantity of protein determined with the Pierce BCA Protein Assay Kit (Prod# 23225, ThermoFisher Scientific, France)
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