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In addition to serum B12, more accurate markers include methylmalonic acid (MMA) and homocysteine levels , especially for people with MTHFR mutations

This has led to interest in NAC for conditions like systemic lupus erythematosus (SLE), where a small RCT found that NAC (2.4-4.8 g/day) improved disease activity scores and reduced anti-dsDNA antibody levels (Lai et al., Lupus, 2012) [42]

Clinical photography and participant self-assessment confirmed improvements in skin roughness, laxity, and clarity reinforcing the dermal-thickening findings from earlier studies

The agencys modern-day role was defined in 1962, after thalidomide caused birth defects in thousands of babies around the world