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Only 4.2% discontinued due to side effects after week 24, indicating symptoms become manageable or resolve for the vast majority who continue treatment
Hence, dose reductions in sulfonylureas and insulin are important considerations when initiating or titrating tirzepatide
What happens if I am not approved for the medication
The appetite suppression timeline also shifts with injection timing, which can help you naturally eat less during peak bloating periods
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![Tirzepatide vs. Semaglutide: Which GLP-1 Better Preserves Muscle? [SURMOUNT-5 Data]](https://www.clinicalnutritioncenter.com/wp-content/uploads/2026/04/research-image-2026-04-10.jpg)
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