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A systematic review and meta-analysis published in Reviews in Endocrine and Metabolic Disorders confirmed it: tirzepatide reduced high-sensitivity C-reactive protein (hsCRP) by a mean difference of -32.9 and interleukin-6 (IL-6) by -17.8 compared to placebo across multiple clinical trials

Interestingly, these residues of the GLP-1R are crucial for intracellular signaling and are responsible for insulin exocytosis

253 Satheesh et al reported that the effects of a moderate blueberry (rather than strawberry) diet on TMAO were not mediated by metabolic changes (TMAO levels in the circulation can be reduced without changing choline or TMA)

What Happens When You Eat Too Little on GLP-1