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Ans: No, the tablet should not be swallowed directly

Abbreviations JS Jia Shi-310 GE Golden Empress-308 GST glutathione S-transferase PPI proteinprotein interactions ROS reactive oxygen species H 2 O 2 hydrogen peroxide MDA malondialdehyde GSSG glutathione oxidized GR glutathione reductase GSH glutathione DHAR dehydroascorbate reductase TCHQD tetrachlorohydroquinone dehalogenase

Once the tumour became arrested in the palbociclib-treated group, mice were further randomized to receive either RSL3 (50 mg kg 1 , five times per week for 2 weeks) or the vehicle, resulting in four experimental groups: vehicle, RSL3, palbociclib and palbociclib + RSL3