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A cohort study showed that there was no decreased risk of fracture with current use of GLP-1RA (sexenatide and liraglutide) compared to never-GLP-1RAs use
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Small, sustainable changes produce better long-term results than trying to overhaul everything at once
Ozempic Trulicity pros Effective at lowering A1C in type 2 diabetes Simple, once-weekly injection with pre-set dosing Easy-to-use pen with no need to dial or measure doses Proven cardiovascular benefits in high-risk patients Widely available and often covered by insurance Trulicity cons May result in only moderate weight loss compared to Ozempic Common side effects include nausea, diarrhea, and fatigue Room temperature stability lasts only 14 days May not be as effective for weight management in some patients Ozempic pros Highly effective at lowering A1C and promoting weight loss Once-weekly injection Proven cardiovascular protection Can be stored at room temperature for up to 56 days Popular choice for patients managing both type 2 diabetes and obesity Ozempic cons May cause more intense gastrointestinal side effects (vomiting, nausea) Dose titration required some pens require manual dose setting Slightly more expensive than Trulicity without insurance Risk of gallbladder issues in rare cases 2025 updates and developments Recent studies have shown the benefits of GLP-1 receptor agonists go beyond glycemic control
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