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cells, proteins, enzymes) and form a stabilizing hydration shell around them
doi: 10.1007/s12035-025-05287-5 84 LiW.FengG.GauthierJ
However, certain SGLT2 inhibitors, such as canagliflozin, may be associated with an increased risk of lower limb amputation (LLA), which is more pronounced in patients with preexisting peripheral arterial disease (PAD) and DN, or prior history of amputation [98]
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