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GHK-Cu also influences the ubiquitin-proteasome system (UPS), upregulating dozens of genes involved in protein degradation and cellular maintenance, thereby supporting proteostasis under stress conditions (Pickart and Margolina 2018)

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GHK-Cu consists of glycine, histidine, and lysine arranged in sequence (Gly-His-Lys), with a Cu ion coordinated by the histidine imidazole, the N-terminal amine, and additional ligand contributions