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Because rapamycin, which extends mouse lifespan 31 , can reverse age-related diastolic dysfunction and restore a more youthful metabolome in the aged myocardium 32 , we next evaluated metabolomic changes in Young, Old Con, and Old mAb female-treated hearts

Figure 1 below depicts the incretin effect in a normal patient versus a diabetic patient

J Clin Endocrinol Metab dgae722 Klonoff DC, Buse JB, Nielsen LL, Guan X, Bowlus CL, Holcombe JH et al (2008) Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years