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While Nrf2 activation provides chemopreventive benefits in preneoplastic and normal cells, its persistent activation in established tumors may paradoxically promote cancer cell survival and confer resistance to conventional chemotherapy (63)
It increased dendritic spine density in hippocampal CA1 neurons and strengthened existing synaptic connections as measured by electrophysiological recordings
Bioavailability limitations require 2-3x higher doses for nasal versus injectable delivery , creating corresponding 2-3x cost increases that make nasal spray primarily appropriate for needle-phobic individuals or peptides specifically designed for nasal use
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