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This can then create false signals where a medication appears to have a higher risk because of increased reporting, not actual incidence

Scaled liver extracts were transferred to bead blaster tubes with zircon beads and homogenized using D2400 BeadBlaster homogenizer (Benchmark Scientific) in cold 80% methanol spiked with 500 nM metabolomics amino acid standard mix (Cambridge Isotopes Laboratory)

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Across multiple studies involving thousands of participants, the results were remarkably consistent