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These include genetic predisposition (the strongest predictor), hormonal factors (estrogen, insulin, thyroid hormones), age-related changes in skin elasticity and thickness, lifestyle factors such as physical inactivity and poor nutrition, and overall body composition

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Approved for type 2 diabetes, Ozempic gained massive off-label use in obesity, supported by real-world weight loss outcomes

Autoimmune progesterone dermatitis (APD), also called progestogen hypersensitivity, is considered a rare condition , though experts believe it is underdiagnosed because symptoms often resemble eczema, chronic hives, PMDD-related flares, or unexplained allergic reactions