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Therefore, it is important to be aware of the existence of this entity due to its possible clinical implications

These additionally internalized receptors are for the most part dimerized with MC3R (Schellekens et al., 2013), suggesting that dimerization with MC3R may not only lead to reduced efficiency of GHSR1a signaling, but also to reduced surface expression of the receptor

Research published in the Journal of Applied Physiology found that chronic central administration of MT-II produced persistent reductions in body mass in experimental models even after the initial appetite-suppressing effects had diminished

The plate was immediately incubated at 37 C in a humidified atmosphere with 5% CO 2 for 4 h