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They know increased glutathione can cause drug resistance by binding or reacting to the drugs, preventing damage to proteins or DNA, or helping repair DNA all these would keep the chemo agents from hurting the cancer cells

222 In a randomized controlled trial in elderly patients with mild cognitive impairment living in the United Kingdom, supplementing with 800 mcg folic acid, 500 mcg B 12 , and 20 mg B 6 daily for two years reduced atrophy of gray matter (brain tissue most vulnerable to Alzheimer pathology) up to seven-fold in those with baseline homocysteine levels higher than 11 mol/L

In contrast, cellular NADP + : NADPH ratio favors maintenance of higher amounts of the reduced NADPH (which is correlated with upregulation of cell protective processes such as higher GSH).[1] NAD + -Dependent Signaling + -Dependent Signaling NAD(P) molecules are shifted back and forth between their oxidized and reduced forms during redox reactions