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Possible Reductions in Side Effects Experienced with Semaglutide While Tirzepatide may have its own set of side effects, some people find it to be better tolerated than Semaglutide, especially if they experienced gastrointestinal discomfort on the latter

It works by activating both GLP-1 and glucose-dependent insulinotropic polypeptide, or GIP, receptors to curb cravings, reduce appetite, and slow stomach emptying