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Plasma was isolated by centrifugation at 17,000 g for 5 min at 4 C and diluted 1:10 in 50% (v/v) glycerol in PBS (pH 7.4) (Sigma-Aldrich) for storage at 20 C until analysis
The MHRA, which is responsible for evaluating the safety, quality, and efficacy of medicines in the UK, has not licensed retatrutide for any indication
Another study evaluating cardiovascular outcomes of GLP-1RAs was the HARMONY study
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