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The Arg3 to Leu3 substitution disrupts a key contact residue in the IGFBP binding interface, and the N-terminal extension further sterically interferes with binding pocket access
P2X 3 -mediates ATP signalling from L-cells to nodose neurons Consistent with the concept of purinergic signalling between L-cells and the afferent vagus nerve, qPCR analysis of fresh and cultured ND ganglion neurones identified expression of P2rx2 and P2rx3 subunits (Fig
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