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B-100 complex can interfere with other medicines including but not limited to: levodopa, medicines containing oestrogen, hydrazine, certain anti epileptic drugs, phenobaritone, phenytoin, immunosuppressants and some drugs used to treat infections such as isoniazid, pyrazinamide, cycloserne and penicillamine
tendon-to-bone integration also noted in preclinical settings (Staresinic 2003
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Theoretical concerns exist for individuals with active cancer due to angiogenic properties, though research hasn't identified increased cancer risk
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