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Several ongoing clinical trials are combining these glutamine-altering drugs with immune checkpoint inhibitors or with inhibitors of receptor tyrosine kinase signaling, the major signal that tells cells to acquire nutrients and grow

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(8) Matthew G Engel, Sushma Narayan, Min-Hui Cui, Craig A Branch, et al (2025) Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice Journal of Alzheimers Disease, 2025 Jan, Volume 103 (Issue 1), Pages 113-126

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