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The short half-life of native GLP-1, typically only 12 min due to rapid degradation, has facilitated the development of structurally modified GLP-1 analogs with longer half-lives, such as liraglutide, exendin-4, and dulaglutide, which exhibit 97%, 53%, and 90% sequence homology, respectively 12
Some private prescribers offer it off-label for weight management, but the NHS wont prescribe it for that purpose
Semaglutide injections used for weight loss purposes in non diabetic individuals can cause other side effects like anxiety
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